NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT
Week 6 Plus-Money Bets
Last week, our NFL bold predictions went 2-1, resulting in a +1.17 unit overall gain. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Predictions
- Fading the Colts offense may not be the wisest choice, but there is a case for doing so.
Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if they maintain this pace all season long.
Author's summary: Explore 3 plus-money NFL bets for Week 6.